The Gunners are favourites heading into that encounter where they will tackle Championship side Sheffield Wednesday and, Arsenal are likely to field a second-string side against the South Yorkshire outfit, with one eye on the Premier League game against Swansea next weekend.
For Arsenal, it is a chance to advance to the quarter-finals and give opportunity to for some fringe players to make their mark.
Ahead of the game on Tuesday, we have pinpointed five players who should start for the Gunners against Sheffield Wednesday.
1. Joel Campbell
The Costa Rica ace remained with the Gunners in the summer, but many have question what his role in the team really is.
Campbell’s impact in the game he has featured is very minimal. Now this is the moment to shine and claim his place in Ramsey’s absence.
2. Matt Macey
With David Ospina out injured and Petr Cech likely to be rested, Macey should get the chance to make his debut for Arsene Wenger’s first team. It is hoped that his experience will the first team helps him succeed against The Owls on Tuesday.
3. Kieran Gibbs
Nacho Monreal has earned his place as Arsenal’s first-choice right-back this season and Gibbs has suffered – finding enough game time hard to come by. The England left-back will now be hoping to impress Wenger against Carlos Carvalhal’s side tomorrow.
Not much has been seen of Gibbs in a defensive role this term, with many of his recent introductions as substitute seeing him play in a more advanced role.
4. Mathieu Debuchy
Debuchy’s situation at Arsenal is similar to that of Gibbs, as Hector Bellerin has kept the Frenchman out of the right-back spot.
Hence, a solid performance will be needed from Debuchy tomorrow in order to warm himself back into the heart of Wenger.
5. Mathieu Flamini
The French midfielder clearly deserves a start after his heroics against Tottenham the last time out in the Capital One Cup. Francis Coquelin needs to be rested and so Flamini should get the nod to provide shield for the Gunners’ rearguard.
His experience will also be helpful against the tricky Championship side.