The Reds would be in need of a victory, having drawn their first two games in the competition against Bordeaux and Sion under former manager Brendan Rodgers.
New boss Jürgen Klopp failed to kick-start his Liverpool career with a win as he had to settle for a draw against Tottenham at White Hart Lane. However, the German tactician will now be looking to inflict defeat on Rubin Kazan on Thursday in order to put the Reds in good stead for qualification out of the group.
Liverpool are second on the log, two points adrift of leaders Bordeaux. A win against the Russian club could turn things around for good.
The Merseyside outfit are without Danny Ings, Joe Gomez, Jordan Henderson, Roberto Firmino, Jordan Rossiter and Jon Flanagan, while there are still doubts over the fitness of strikers Christian Benteke and Daniel Sturridge, as well as centre-back Dejan Lovren.
Liverpool are better placed to win this game, with Rubin Kazan currently 12th in their domestic league and rock bottom of their group in the Europa League. Hence, Klopp will be hoping his boys help deliver his first win as boss of the Reds.
Here is how we have predicted the Liverpool line-up:
Mignolet; Nathaniel Clyne, Mamadou Sakho, Martin Škrtel, Alberto Moreno; Emre Can, Philippe Coutinho, Adam Lallana, Lucas Leiva, James Milner; Daniel Sturridge.